GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2243480 | 1 | rs4718333 | chr7:65772758 | CCT6P1 | chr7:65216092-65228661:+ | -0.64 | -5.29 | 7.77E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs4718334 | chr7:65789454 | CCT6P1 | chr7:65216092-65228661:+ | -0.64 | -5.22 | 1.03E-6 | Diabetic kidney disease |
| THYM | cis | rs477692 | 1 | rs473073 | chr10:131429646 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.48 | 2.06E-5 | Response to temozolomide |
| THYM | cis | rs477692 | 1 | rs473771 | chr10:131408155 | MGMT | chr10:131265454-131565783:+ | 0.3 | 4.15 | 7.2E-5 | Response to temozolomide |
| THYM | cis | rs477692 | 1 | rs4750759 | chr10:131436603 | MGMT | chr10:131265454-131565783:+ | -0.29 | -4.22 | 5.52E-5 | Response to temozolomide |
| THYM | cis | rs3136441 | 1 | rs4752946 | chr11:46896908 | CKAP5 | chr11:46765084-46867843:- | 0.25 | 4.24 | 5.16E-5 | HDL cholesterol |
| THYM | cis | rs4237643 | 1 | rs4755726 | chr11:43642130 | HSD17B12 | chr11:43702143-43878160:+ | -0.57 | -5.83 | 7.53E-8 | Forced vital capacity |
| THYM | cis | rs877636 | 1 | rs4759229 | chr12:56474480 | RPS26 | chr12:56435686-56438005:+ | -0.93 | -9.89 | 2.9E-16 | Cognitive function |
| THYM | cis | rs7301826 | 1 | rs4759523 | chr12:131315412 | STX2 | chr12:131274149-131323811:- | 0.35 | 5.89 | 5.79E-8 | Plasma plasminogen activator levels |
| THYM | cis | rs7301826 | 1 | rs4759524 | chr12:131315610 | STX2 | chr12:131274149-131323811:- | 0.35 | 5.89 | 5.79E-8 | Plasma plasminogen activator levels |
| THYM | cis | rs7301826 | 1 | rs4759787 | chr12:131290180 | STX2 | chr12:131274149-131323811:- | 0.35 | 5.89 | 5.79E-8 | Plasma plasminogen activator levels |
| THYM | cis | rs7301826 | 1 | rs4759793 | chr12:131297238 | STX2 | chr12:131274149-131323811:- | 0.35 | 5.89 | 5.79E-8 | Plasma plasminogen activator levels |
| THYM | cis | rs4763879 | 1 | rs4763879 | chr12:9910164 | CLECL1 | chr12:9868457-9885860:- | -0.41 | -4.43 | 2.52E-5 | Type 1 diabetes |
| THYM | cis | rs7989332 | 1 | rs4769117 | chr13:21054724 | GJB2 | chr13:20761606-20767114:- | -0.36 | -4.61 | 1.23E-5 | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) |
| THYM | cis | rs4794202 | 1 | rs4794202 | chr17:45930539 | SCRN2 | chr17:45915049-45918699:- | -0.35 | -4.6 | 1.32E-5 | Alzheimer's disease (cognitive decline) |